L-Thyroxine-N-methylamide

Size

£314.00

SKU:: 453713
Molecular Weight:: 789.91
Purity:: ≥90%
Storage Conditions:: 4°C
Supplier:: United States Biological
CAS Number:: 2088032-52-2
Format:: Pale brown to beige solid
Extra Details:: L-Thyroxine-N-methylamide (Levothyroxine N-Methylamide) is an impurity of Thyroxine, one of the thyroid hormones involved in the maintenance of metabolic homeostasis. Synthesized and stored as amino acid residues of thyroglobulin, the major protein component of the thyroid follicular colloid. Synthesis and secretion are regulated by the pituitary hormone (TSH). Deiodinated in peripheral tissues to the active metabolite, liothyronine. The D-form has very little activity as a thyroid hormone, but has been used to treat hyperlipidemia. Synonyms: Levothyroxine N-Methylamide; (S)-2-Amino-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)-N-methylpropanamide; αS-amino-4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodo-N-methyl-benzenepropanamide CAS No: 2088032-52-2 Molecular Formula: C₁₆H₁₄I₄N₂O₃ Molecular Weight: 789.91 Appearance: Pale brown to beige solid Purity: ≥90% Melting Point: >125°C (dec.) Solubility: DMF: 10mg/ml; DMSO: 10mg/ml; Ethanol: Slightly soluble; PBS (pH 7.2): 0.20mg/ml Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.