453199
L-alpha-Lysophosphatidylcholine (from egg yolk)
Size
£279.00
- SKU:
- 453199
- Purity:
- ≥99% (TLC)
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- CAS Number:
- 9008-30-4
- Format:
- White powder
- Extra Details:
- L-alpha-Lysophosphatidylcholine (from egg yolk) is a major component of oxidized low density lipoproteins that has been implicated in various inflammatory reactions. Lysophosphatidylcholines are produced by hydrolysis of the fatty acid of phosphatidylcholine at either the sn-1 or sn-2 position by phospholipase A2 (PLA2) or by lecithin-cholesterol acyltranferase (LCAT), which transfers the fatty acid to cholesterol.1 Lysophosphatidylcholine has effects on a variety of cell types, including smooth muscle cells, endothelial cells, T lymphocytes, monocytes, and macrophages among others. It is a major phospholipid component of oxidized low-density lipoprotein (ox-LDL), and it accumulates in animal models of atherosclerosis. Lysophosphatidylcholine also has pro-inflammatory properties through its activation and modulation of various signaling pathways, including the ERK pathway as well as through protein tyrosine kinase and G protein-coupled receptor (GPCR) signal transduction. It is released from apoptotic cells in vitro following caspase-3 activation of the calcium-independent PLA2 and acts as a chemoattractant for monocytes.2 Lysophosphatidylcholine (2 µl, 1%) injected into the caudal cerebellar peduncle of rats induces demyelination of axons in vivo, which are extensively remyelinated by oligodendrocytes six weeks following injection.3 Lysophosphatidylcholines (egg) is a mixture of lysophosphatidylcholines isolated from chicken egg that has a fatty acid of variable chain length acylated to the sn-1 or sn-2 position. Synonyms: L-α-Lysolecithin; 1-Acyl-sn-glycero-3-phosphocholine CAS Number: 9008-30-4 Appearance: White powder Purity: ≥99% (TLC) Solubility: Chloroform:Methanol (2:1): 2:1 Storage and Stability: Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
- Shipping Conditions:
- Ambient