451503
Guaiol
Size
£320.00
- SKU:
- 451503
- Molecular Weight:
- 222.37
- Purity:
- ≥95%
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- CAS Number:
- 489-86-1
- Format:
- White to off-white solid
- Extra Details:
- (−)-Guaiol is a sesquiterpene alcohol that has been found in several traditional Chinese medicinal plants and has antiproliferative, pro-autophagic, insect repellent, and insecticidal biological activities.1,2,3 It selectively inhibits proliferation of A549 and H1299 non-small cell lung carcinoma (NSCLC) cells over BEAS-2B normal lung cells (IC50s = 121.7, 211.5, and 297.1 μM, respectively).1 It also dose-dependently induces formation of DNA double-strand breaks (DSBs) and autophagy in A549 and H1299 cells and increases levels of microtubule-associated protein 1 light chain 3 isoform II (LC3-II). (−)-Guaiol (8 mg/kg three times per week) inhibits tumor growth in an NSCLC mouse xenograft model. It deters A. aegypti and A. quadrimaculatus mosquitoes from feeding on a synthetic blood substitute with a biting-deterrent index (BDI) of 0.82 when used at a concentration of 25 nmol per cm2.2 (−)-Guaiol is also lethal to fourth instar M. separata and third instar P. xylostella larvae (LD50s = 0.07 and 8.9 mg/larva, respectively).3 Synonyms: 1,2,3,4,5β,6,7,8-Octahydro-α,α,3α,8α-tetramethyl-5-azulenemethanol_x000B_Guai-1(5)-en-11-ol; Guaiol; (3S,5R,8S)-1,2,3,4,5,6,7,8-Octahydro-α,α,3,8-tetramethyl-5-azulenemethanol; (-)-Guaiol; 3,8-Dimethyl-5-α-hydroxyisopropyl-Δ9-octahydroazulene; Champaca Camphor; Champacol; Guaiac Alcohol; NSC 19941 CAS No: 489-86-1 Molecular Formula: C₁₅H₂₆O Molecular Weight: 222.37 Appearance: White to off-white solid Purity: ≥95% Melting Point: 89-91°C Solubility: Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly) Storage and Stability: Store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
- Shipping Conditions:
- Blue Ice