Genistein 7-Sulfate Sodium Salt

Size

£575.00

SKU:: 451137
Molecular Weight:: 372.28
Purity:: ≥97% (HPLC)
Storage Conditions:: -20°C
Supplier:: United States Biological
CAS Number:: 182322-62-9 free acid
Format:: Off-white to pale beige solid
Extra Details:: Genistein 7-Sulfate Sodium Salt is a derivative of Genistein (446-72-0). Genistein exhibits specific inhibitory activity against tyrosine kinases,including autophosphorylation of epidermal growth factor receptor kinase (IC50 - 2.6uM). Also inhibits other protein kinases through competitive inhibition of ATP. Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell-cycle arrest and apoptosis in Jurat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Genistein also inhibits topoisomerase II activity in vitro. Genistein has also been shown to inhibit the action of GABA on recombinant GABAA receptors 2. uv(max)ethanol: 262.5 nm (e= 138). moderately sol. in hot alcohol. Synonyms: 5-Hydroxy-3-(4-hydroxyphenyl)-7-(sulfooxy)-4H-1-benzopyran-4-one Sodium Salt Molecular Formula: C15H9NaO8S Molecular Weight: 372.28 Appearance: Off-white to pale beige solid Purity: ≥97% (HPLC) NMR, MS: Conforms to reference Elemental Analysis: %C: 44.37, %H: 2.67 Solubility: DMSO (Slightly), Ethyl Acetate (Slightly) Storage and Stability: Store at -20°C. Hygroscopic. For maximum recovery of product, centrifuge the original vial prior to removing the cap.