451022
G-1
Size
£351.00
- SKU:
- 451022
- Molecular Weight:
- 412.28
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- CAS Number:
- 881639-98-1
- Format:
- Supplied as a Off-White Solid
- Extra Details:
- G-1 is a potent and selective G protein-coupled estrogen receptor (GPER) agonist (Ki = 11 nM, EC50 = 2 nM); displays no activity at ERα and ERβ at concentrations up to 10 μM. Increases cytosolic Ca2+ and inhibits migration of SKBr3 cells and MCF-7 cells in response to chemoattractants (IC50 values are 0.7 and 1.6 nM respectively) in vitro. Blocks MCF-1 cell cycle progression at the G1 phase. Displays therapeutic effects in the mouse EAE model of multiple sclerosis. Molecular Formula: C21H18BrNO3 Solubility: DMSO (Slightly), Methanol (Slightly, Heated) Molecular Weight: 412.28 Storage and Stability: Store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
- Shipping Conditions:
- Ambient