Di-O-glycinoylcurcumin Dihydrochloride

Size

£422.00

SKU:: 446500
Molecular Weight:: 555.4
Storage Conditions:: -20°C
Supplier:: United States Biological
CAS Number:: 1322544-82-0
Format:: Supplied as a Yellow Solid
Extra Details:: Di-O-glycinoylcurcumin Dihydrochloride is a metabolite of curcumin (C838500), which is a natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and antioxidant properties. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope. Curcumin is currently being examined as a possible therapeutic for the treatment of Alzheimers disease (Chem. and Eng. News 90(31), 44 (2012)). Molecular Formula: C25H28Cl2N2O8 Solubility: DMSO (Slightly), Methanol (Slightly) Molecular Weight: 555.4 Storage and Stability: Store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.