CRANAD 28

Size

£253.00

SKU:: 445116
Molecular Weight:: 484.3
Purity:: ≥98% (HPLC)
Storage Conditions:: -20°C
Supplier:: United States Biological
CAS Number:: 1623747-97-6
Format:: Crystalline solid
Extra Details:: CRANAD 28 is a curcumin derivative and non-conjugated fluorescent affinity probe for the detection of amyloid-β (Aβ) in vitro and in vivo that has excitation/emission spectra of 498/578nm, respectively.1 It binds to various forms of Aβ, including Aβ40 monomers and aggregates, as well as Aβ42 monomers, dimers, and oligomers (Kds = 68.8, 52.4, 159.7, 162.9, and 85.7nM, respectively). When bound to Aβ, the fluorescence intensity decreases, in contrast to similar curcumin-based fluorescent probes. CRANAD 28 labels amyloid plaques and cerebral amyloid angiopathy both in APP/PS1 mouse brain sections and in live mice following i.v. administration. It also inhibits copper-induced and naturally occurring Aβ crosslinking. Synonyms: (T-4)-[(1E,6E)-1,7-Bis[4-(dimethylamino)phenyl]-1,6-heptadiene-3,5-dionato-kO3,kO5]difluoroboron CAS No: 1623747-97-6 Molecular Formula: C27H23BF2N4O2 Molecular Weight: 484.3 Appearance: As reported Purity: ≥98% (HPLC) Emission: 578nm Excitation: 498nm λmax: 245, 479nm Solubility: DMF: 2mg/ml DMSO: 2mg/ml DMSO:PBS (pH 7.2) (1:1): 0.5mg/ml Storage and Stability: Store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.