443743
Cabozantinib L-Malate Salt
Size
£345.00
- SKU:
- 443743
- Molecular Weight:
- 635.59
- Purity:
- ≥98%
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- CAS Number:
- 1140909-48-3
- Format:
- White to off-white solid
- Extra Details:
- Cabozantinib is a small molecule C-Met modulator. Cabozantinib acts as a potent multitargeted VEGFR2, Met, FLT3, Tie2, Kit and Ret inhibitor with IC50 of 0.035, 1.8, 14.4, 14.3 and 4.6 nM for VEGFR2, Met, FLT3, Tie2 and Kit, respectively. Cabozantinib shows dose-dependent inhibition of tumor growth and tumor regression, associated with disruption of the tumor vasculature and extensive tumor cell apoptosis. Synonyms: N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide (2S)-2-Hydroxybutanedioic Acid; Cabozantinib S-Malate; XL 184 CAS No: 1140909-48-3 Molecular Formula: C₂₈H₂₄FN₃O₅•C₄H₆O₅ Molecular Weight: 635.59 Appearance: White to off-white solid Purity: ≥98% Melting Point: 166-169°C Solubility: DMSO (Slightly), Methanol (Slightly, Heated), Pyridine (Slightly) Storage and Stability: Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
- Shipping Conditions:
- Ambient