442678
BI-847325
Size
£294.00
- SKU:
- 442678
- Molecular Weight:
- 464.56
- Purity:
- ≥99%
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- CAS Number:
- 1207293-36-4
- Format:
- Crystalline solid
- Extra Details:
- BI-847325 is a novel ATP-competitive MEK and Aurora kinase inhibitor. It can inhibit the growth of BRAF resistant melanoma cells through suppression of Mcl-1 and MEK expression in human melanoma cell lines and mouse xenograft model. The efficacy of BI-847325 was studied in patients with refractory solid tumors. Synonyms: 3-[3-[[[4-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-1H-indol-6-yl]-N-ethyl-2-propynamide; (Z)-3-(3-(((4-((Dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-2-oxoindolin-6-yl)-N-ethylpropiolamide; BI 847325 CAS No: 1207293-36-4 Molecular Formula: C₂₉H₂₈N₄O₂ Molecular Weight: 464.56 Appearance: Crystalline solid Purity: ≥99% Solubility: DMF: 16mg/ml DMF:PBS(pH 7.2)(1:6): 0.14mg/ml DMSO: 5mg/ml Ethanol: 0.3mg/ml Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
- Shipping Conditions:
- Ambient