440732
Ac-DEVD-AFC
Size
£275.00
- SKU:
- 440732
- Molecular Weight:
- 729.61
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- CAS Number:
- 201608-14-2
- Extra Details:
- Ac-DEVD-AFC is a fluorogenic substrate for caspase-3 (CPP32) and related cysteine proteases, which emits a blue to green shift in fluorescence. It also acts as a substrate for granzyme B-processed caspase-6, caspase-7, caspase-8, and caspase-10. It is known that Ac-DEVD-AFC has a greater Stokes' shift than Ac-DEVD-AMC once it has been cleaved. Since caspase-3 is an effector caspase, it is involved in the cleavage of many substrates which promote apoptosis. This indicator excites light at 400 nm and emits light at 505 nm. In addition, Ac-DEVD-AFC is modeled after Asp216 on caspase-3, the PARP cleavage site. Ac-DEVD-AFC is an essential indicator used to monitor the cellular effects of caspase-3. Molecular Formula: C30H34F3N5O13 Molecular Weight: 729.61 Storage and Stability: Store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
- Shipping Conditions:
- Ambient