3-Bromo-1,4-dihydro-4-oxo-1-(2-oxoethyl)-2,5-pyridinedicarboxylic Acid 2,5-Diethyl Ester

Size

£288.00

SKU:: 424097
Molecular Weight:: 360.16
Storage Conditions:: -20°C
Supplier:: United States Biological
CAS Number:: 1246616-77-2
Format:: Supplied as a Solid
Extra Details:: 3-Bromo-1,4-dihydro-4-oxo-1-(2-oxoethyl)-2,5-pyridinedicarboxylic Acid 2,5-Diethyl Ester is an intermediate in the synthesis of Defluoro Dolutegravir (D228715). Defluoro Dolutegravir is an impurity of Dolutegravir (D528800), a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector. Molecular Formula: C13H14BrNO6 Molecular Weight: 360.16 Storage and Stability: Store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.