396997
CD172a (MyD-1 Antigen, SIRP Alpha)
Size
£594.00
- SKU:
- 396997
- Application:
- Flow Cytometry
- Purity:
- Supernatant
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Mouse
- Immunogen:
- Cells from multiple species with the final screening of the fusion on cells from canine.
- Clone:
- DH59B
- Format:
- Supplied as a liquid, 0.09% sodium azide.
- Extra Details:
- CD172a is a transmembrane signal regulatory protein expressed primarily by macrophages, monocytes, dendritic cells, granulocytes, myeloid progenitors, hematopoietic stem cells, and neurons. The extracellular region of SIRP family consists of three immunoglobulin superfamily (IgSF) domains; two IgC and one IgV domain. The IgV domain of CD172a binds to CD47.The binding domain of CD172a is analogous to that of immunoglobulins and T cell receptors and is involved in myeloid cell activation. However, signaling via CD172a is mainly inhibitory to cell function and phagocytosis. CD172a expressing cells are stimulated in Mycobacterium tuberculosis infection, influencing migration of dendritic cells and macrophages, phagocytosis, and granuloma formation. Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilution: Flow Cytometry: Neat Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice