IL4R, Recombinant, Human, aa26-232, His-Tag (Interleukin 4 Receptor Subunit Alpha Isoform, IL4R, CD124, IL-4RA, IL4RA)

Size

£544.00

SKU:: 396889
Molecular Weight:: 24.7
Purity:: ~95% (SDS-PAGE)
Storage Conditions:: 4°C/-20°C
Supplier:: United States Biological
Format:: Supplied as a liquid in PBS, pH 7.4.
Extra Details:: IL4R, also known as interleukin 4 receptor subunit alpha isoform, is a pleiotropic cytokine produced by T lymphocytes. It plays an important role in immune responsiveness by regulating proliferation and differentiation of a variety of lymphoid and myeloid cells via binding to high affinity receptors. It markedly inhibits IL-1 production by highly purified normal human monocytes. It has been demonstrated to affect the growth of different human malignancies including pancreatic cancer cells. It plays an important role in Th2-biased immune responses, alternative macrophage activation, mucosal immunity, allergic inflammation, tumor progression, and atherogenesis. Recombinant human IL4R, fused to His-Tag at C-terminal, was expressed in insect cell and purified by using conventional chromatography techniques. Source: Recombinant protein corresponding to aa26-232 of human IL4R, fused to His-Tag at C-terminal, was expressed in insect cell. Molecular Weight: ~24.7kD (215aa), ~28-40kD (SDS-PAGE under reducing conditions) Endotoxin: <1EU/1ug (determined by LAL method) AA Sequence: MKVLQEPTCV SDYMSISTCE WKMNGPTNCS TELRLLYQLV FLLSEAHTCI PENNGGAGCV CHLLMDDVVS ADNYTLDLWA GQQLLWKGSF KPSEHVKPRA PGNLTVHTNV SDTLLLTWSN PYPPDNYLYN HLTYAVNIWS ENDPADFRIY NVTYLEPSLR IAASTLKSGI SYRARVRAWA QCYNTTWSEW SPSTKWHNSY REPFEQHLEH HHHHH Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Shipping Conditions:: Blue Ice