396821
Pepsinogen I (PGI, PGA, Pepsinogen A3/A4/A5, EC 3.4.23.1), Human
Size
£460.00
- SKU:
- 396821
- Molecular Weight:
- 45
- Purity:
- ≥90% by SDS-PAGE (identity confirmed by Western blot)
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Format:
- Supplied as a white, lyophilized powder in Tris-chloride, pH 8.5.
- Extra Details:
- Human Pepsinogens are aspartic proteases produced in the gastric mucosa and secreted into the gastric lumen that play a major role in the digestion of proteins after activation of acidic pH. It is synthesized as isoymogens and are classified into two groups, Pepsinogen I and Pepsinogen II). Human PGA and PGC antigen have been investigated as a possible biomarker for early detection of, Gastric cancer (GC), adenoma (GA) and severe atrophic (diffuse or patchy) corpus gastritis. It has been reported that human Pepsinogen I (PGA) levels were lower in atrophic corpus gastritis than in atrophic antral gastritis, and human pepsinogen I (PGA) levels were lower in advanced gastric cancer than early stage gastric cancer. Synonyms: Pepsinogen A, PG I, PGA, Pepsinogen 1; E.C. Number 3.4.23.1; Gene: PGA3, PGA4, PGA5 Molecular Weight: 45kD Appearance: Supplied as a white, lyophilized powder in Tris-chloride, pH 8.5. Source: Human gastric mucosa Purity: ≥90% by SDS-PAGE (identity confirmed by Western blot) Solubility: Clear colorless liquid at 1mg/ml in saline Specific Activity: Lot-dependent. ≥500U/mg protein (upon activation) Note: Pepsinogen self-activates upon exposure to low pH. Unit Definition of Activity: One unit will produce a ΔA280 of 0.001 per minute at pH 2.0 and 37°C, measured as TCA-soluble products from hemoglobin. Storage and Stability: Store lyophilized powder at -20°C for up to 12 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
- Shipping Conditions:
- Blue Ice