385058
Alpha Synuclein, phosphorylated (pSer129) (Alpha-Synuclein, Alpha-Synuclein, Isoform NACP140, AlphaSYN, NACP, Non A Beta Component Of AD Amyloid, Non A4 Component Of Amyloid, Non A4 Component Of Amyloid Precursor, Non-A Beta Component Of AD Amyloid, Non-A-Beta Component Of Alzheimers Disease Amyloid, Non-A4 Component Of Amyloid Precursor, Non-A4 Component Of Amyloid, PARK 1, PARK 4, PARK1, PARK4, Parkinson Disease (Autosomal Dominant, Lewy Body) 4, Parkinson Disease Familial 1, SNCA, Alpha (Non A4 Component Of Amyloid Precursor), SYN, Synuclein Alpha, Synuclein Alpha 140, Synuclein, Alpha (Non A4 Component Of Amyloid Precursor), SYUA HUMAN)
Size
£590.00
- SKU:
- 385058
- Purity:
- Purified by peptide affinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide corresponding to aa40-140 of human Alpha Synuclein pSer129, conjugated to KLH.
- Format:
- Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide, 50% glycerol.
- Extra Details:
- Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals (1). Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum and thalamus (2). Functionally, it has been shown to significantly interact with tubulin (3), and may serve as a potential microtubule-associated protein. It has also been found to be essential for normal development of the cognitive functions; inactivation may lead to impaired spatial learning and working memory (4). SNCA fibrillar aggregates represent the major non A-beta component of Alzheimers disease amyloid plaque, and a major component of Lewy body inclusions, and Parkinson’s disease. Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin (5, 6). Alpha synuclein phosphorylated at serine 129 constitutes 90% of the alpha synuclein found in Lewy bodies (7, 8). Applications: Suitable for use in Western Blot, ELISA, Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:1000 Immunohistochemistry: 1:500 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice