385057
PIK3CA (PI 3 Kinase Catalytic Subunit Alpha, Phosphoinositide 3 Kinase Catalytic Alpha Polypeptide, PI3 Kinase p110 Subunit Alpha, PtdIns 3 Kinase p110, PtdIns 3 Kinase Regulatory Subunit Alpha, Phosphatidylinositol 3 Kinase Regulatory Subunit Polypeptide 1, GRB1, PtdIns 3 Kinase Subunit p110 Alpha, Phosphoinositide 3 Kinase Regulatory Subunit 1 (Alpha), PtdIns-3-Kinase Subunit p110-Alpha, PtdIns-3-Kinase Subunit Alpha, PtdIns 3 Kinase Regulatory Subunit p85 Alpha, p110alpha, Phosphatidylinositol 4 5 Bisphosphate 3 Kinase Catalytic Subunit Alpha Isoform, Phosphatidylinositol 3 Kinase Regulatory 1, Phosphatidylinositol 4 5 Bisphosphate 3 Kinase 110kD Catalytic Subunit Alpha, PIK3R1, EC:2.7.11.1, Phosphoinositide-3-Kinase Catalytic Alpha Polypeptide, PI3K Alpha, PI3-Kinase Subunit Alpha, Phosphatidylinositol 3 Kinase Catalytic Alpha Polypeptide, p110 Alpha, Phosphatidylinositol 3 Kinase Regulatory Subunit Alpha, Phosphatidylinositol 3 Kinase Catalytic 110kD Alpha, 5-Bisphosphate
Size
£626.00
- SKU:
- 385057
- Application:
- WB
- Purity:
- Purified by peptide affinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide corresponding to aa150-250 of human PIK3CA, conjugated to KLH.
- Format:
- Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide, 50% glycerol.
- Extra Details:
- PI3 Kinase (Phosphatidylinositol 3-Kinase) is responsible for phosphorylation of the 3 position of the inositol ring of PI(4,5)P2, to generate PI(3,4,5)P3, a potent second messenger required for survival, signaling, and insulin action. PI3 Kinase is a heterodimeric complex composed of an 85kD regulatory subunit and a 110kD catalytic subunit. Tyrosine phosphorylation of growth factor receptors creates docking sites for binding of p85 (through its SH2 domains) on the receptors; p85 brings with it p110, which is then proximal to its phospholipid substrate on the membrane. PI3 Kinase is also activated by Ras, and by the beta:gamma subunits of heterotrimeric G-proteins. PI3 Kinase is inhibitable by wortmannin, a useful tool for the study of the PI3 Kinase signaling pathway. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice