384917
JIP2 (IB2, MAPK8IP2, C Jun Amino Terminal Kinase Interacting Protein 2, C-Jun-Amino-Terminal Kinase-Interacting Protein 2, Homologous To Mouse JIP 1, IB 2, IB-2, IB2, Islet Brain 2, Islet-Brain-2, JIP 2, JIP-2, JIP2, JNK Interacting Protein 2, JNK MAP Kinase Scaffold Protein 2, JNK MAP Kinase Scaffold Protein JIP2, JNK-Interacting Protein 2, MAPK8IP2, Mitogen Activated Protein Kinase 8 Interacting Protein 2, Mitogen-Activated Protein Kinase 8-Interacting Protein 2, PRKM8 Interacting Protein Like, PRKM8IPL)
Size
£626.00
- SKU:
- 384917
- Purity:
- Purified by Protein G affinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Mouse
- Immunogen:
- Fusion protein corresponding to aa226-421 of mouse JIP2. Species sequence homology: human (aa173/200) (86%), rat (aa127/135) (94%)
- Clone:
- S135-37
- Format:
- Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide, 50% glycerol.
- Extra Details:
- The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. It is expressed mainly in the cerebellum, pituitary gland, occipital lobe, and the amygdala of the brain, but also in the pancreas, including insulin-secreting cells. Applications: Suitable for use in Western Blot, Immunocytochemistry/Immunofluorescence. Other applications not tested. Recommended Dilution: Western Blot: 1:1000 Immunocytochemistry/Immunofluorescence: 1:100 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice