INPP5F (EC 3.1.3.36, Inositol Polyphosphate 5 Phosphatase OCRL 1, Inositol Polyphosphate 5 Phosphatase OCRL1, Inositol Polyphosphate 5-Phosphatase OCRL-1, INPP5F, LOCR, Lowe Oculocerebrorenal Syndrome Protein, NPHL2, OCRL, OCRL HUMAN, OCRL1, Oculocerebrorenal Syndrome Of Lowe, Phosphatidylinositol Polyphosphate 5 Phosphatase)

Size

£626.00

SKU:: 384916
Purity:: Purified by Protein G affinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Mouse
Immunogen:: Fusion protein corresponding to aa1-901 of full-length human INPP5F. Species sequence homology: mouse (aa824/901) (91%), rat (aa845/904) (93%)
Clone:: S166A-26
Format:: Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide, 50% glycerol.
Extra Details:: Inositol polyphosphate 5-phosphatase OCRL-1 (INPP5F/OCRL) is also called Lowe oculocerebrorenal syndrome protein. INPP5F is a phosphotase that converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate, as well as inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate. ORCL is involved in primary cilia assembly and may also have a role in lysosomal membrane trafficking. ORCL is expressed in brain, skeletal muscle, heart, kidney, lung, placenta, fibroblasts, retina and the retinal pigment epithelium. INPP5F defects can cause Lowe oculocerebrorenal syndrome (OCRL) and Dent disease type 2 (DD2). Applications: Suitable for use in Western Blot, Immunocytochemistry/Immunofluorescence. Other applications not tested. Recommended Dilution: Western Blot: 1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Shipping Conditions:: Blue Ice