ATF4 (Activating Transcription Factor 4, ATF 4, ATF4 Protein, cAMP-Dependent Transcription Factor ATF-4, cAMP-Responsive Element-Binding Protein 2, CREB 2, CREB-2, CREB2, Cyclic AMP Dependent Transcription Factor ATF 4, Cyclic AMP Response Element Binding Protein 2, Cyclic AMP Response Element Binding Protein 2, Cyclic AMP-Dependent Transcription Factor ATF-4, Cyclic AMP-Responsive Element-Binding Protein 2, DNA Binding Protein TAXREB67, DNA Binding Protein TAXREB67, DNA-Binding Protein TAXREB67, Tax Responsive Enhancer Element B67, Tax-Responsive Enhancer Element-Binding Protein 67, TAXREB67, TXREB)

Size

£626.00

SKU:: 384901
Purity:: Purified by Protein G affinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Mouse
Immunogen:: Fusion protein corresponding to aa25-327 of human ATF4.
Clone:: S360A-24
Format:: Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide, 50% glycerol.
Extra Details:: Cyclic AMP-dependent transcription factor ATF-4 (ATF4) is a basic leucine-zipper (bZip) transcription factor, which regulates amino acid metabolism, DNA damage repair, chromatin remodeling, and apoptosis in response to cellular and ER stress. ATF4 works with various proteins, such as C/EBP homology protein (CHOP), aspargine synthetase (ASNS), and cAMP response element (CRE) among others to mediate cellular stress. ATF4 also regulates glucose homeostasis by suppressing beta-cell proliferation and insulin production. Furthermore, ATF4 targets the histone demethylase JMJD3 to alter chromatin structure and enhance gene transcription in response to amino acid deprivation. Applications: Suitable for use in Western Blot, Immunocytochemistry/Immunofluorescence, Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Shipping Conditions:: Blue Ice