LRRFIP1 (FLAP1, FLIIAP 1, GC Binding Factor 2, GCF2, HUFI1, Leucine Rich Repeat (in FLII) Interacting Protein 1, Leucine Rich Repeat Flightless interacting Protein 1, LRR FLII Interacting Protein 1, LRRFIP 1, Lrrfip1, NEDD8 Conjugating Enzyme, TAR RNA interacting Protein, TAR RNA-interacting Protein, Transcription Factor 9 Like, TRIP)

Size

£633.00

SKU:: 381650
Application:: WB
Purity:: Purified by affinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Mouse
Immunogen:: Recombinant protein corresponding to LRRFIP1.
Clone:: 17J88
Format:: Supplied as a liquid in 0.1M Tris-HCl, pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
Extra Details:: Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.