KMT3C (Histone Methyltransferase SMYD2, HSKM B, HSKM-B, HSKMB, KMT3C, Lysine N-Methyltransferase 3C, N lysine Methyltransferase SMYD2, N-Lysine Methyltransferase SMYD2, SET And MYND Domain Containing 2, SET And MYND Domain Containing Protein 2, SET And MYND Domain-Containing Protein 2, Smyd2, SMYD2 HUMAN, Zinc Finger MYND Domain Containing 14, ZMYND14)

Size

£633.00

SKU:: 381645
Application:: WB
Purity:: Ascites
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Mouse
Immunogen:: Recombinant protein corresponding to KMT3C.
Clone:: 17J83
Format:: Supplied as a liquid, 0.09% sodium azide.
Extra Details:: Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.