IFT57 (Intraflagellar Transport Protein 57 Homolog, Dermal Papilla-Derived Protein 8, Estrogen-Related Receptor Beta-Like Protein 1, HIP1-Interacting Protein, MHS4R2, IFT57, DERP8, ESRRBL1, HIPPI)

Size

£698.00

SKU:: 381632
Purity:: Purified by Protein A affinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: Synthetic peptide corresponding to aa159-193 from human IFT57, KLH conjugated. Species Sequence Homology: bovine.
Format:: Supplied as a liquid in PBS, 0.09% sodium azide.
Extra Details:: Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro- apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear. Applications: Suitable for use in Western Blot, ELISA. Other applications not tested. Recommended Dilution: Western Blot: 1:2000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.