LRP1B (Low Density Lipoprotein Receptor Related Protein 1B, LRPDIT, LRP-DIT (Deleted In Tumors), Low-density Lipoprotein Receptor-related Protein-deleted in Tumor)

Size

£626.00

SKU:: 369563
Purity:: Purified by immunoaffinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: LRP1B (Leu31~Lys194)
Format:: Supplied as a liquid in 0.01M PBS, pH 7.4, 0.05% Proclin-300, 50% glycerol.
Extra Details:: LRP1B belongs to the low density lipoprotein (LDL) receptor gene family. full-length LRP1B was unstable following transfection in Lrp1 null Chinese hamster ovary (CHO) cells. In order to characterize the ligands for LRP1B, generated a minireceptor of LRP1B that could be stably expressed in CHO cells. The minireceptor began with the EGF precursor-like repeat before the fourth cluster of ligand-binding repeats (domain IV) and contained ligand-binding domain IV, the transmembrane domain, and the cytoplasmic tail. Ligands for the minireceptor, including receptor-associated protein , urokinase plasminogen activator, tissue-type plasminogen activator , and plasminogen activator inhibitor-1, were bound, internalized, and degraded via their association with the minireceptor. Applications: Suitable for use in ELISA, Western Blot, Immunoprecipitation, Immunohistochemistry, Immunocytochemistry. Other applications not tested. Recommended Dilution: ELISA: 0.05-2ug/ml Western Blot: 0.05-2ug/ml Immunohistochemistry (frozen): 5-20ug/ml Immunohistochemistry (paraffin): 5-20ug/ml Immunocytochemistry: 5-20ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Shipping Conditions:: Blue Ice