369458
Aquaporin 5 (AQP5)
Size
£512.00
- SKU:
- 369458
- Purity:
- Purified by Protein A and peptide affinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide corresponding to DEDWEEQREERKKTMELTTR of human AQP5 conjugated to OVA.
- Format:
- Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
- Extra Details:
- Sidhaye et al. (2006) observed a dose-responsive decrease in Aqp5 abundance in mouse lung epithelial cells exposed to hypotonic medium. Hypotonic reduction of AQP5 was augmented and reduced, respectively, by conditions that activated or inhibited Trpv4. Hypotonic reduction of AQP5 required extracellular calcium and was associated with increased intracellular calcium. The response to hypotonicity was recapitulated by coexpression of TRPV4 and AQP5 in human embryonic kidney cells. Sidhaye et al. (2006) concluded that AQP5 abundance is tightly controlled along a spectrum of extracellular osmolalities and that its abundance in hypotonic conditions can be regulated by TRPV4 activation. Applications: Suitable for use in ELISA and Immunohistochemistry. Other applications not tested. Recommended Dilutions: Immunohistochemistry (Paraffin): 5-20ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice