Netrin-1 (NTN1)

Size

£492.00

SKU:: 368508
Purity:: Purified by Protein A affinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Human
Immunogen:: Recombinant protein corresponding to human Netrin-1 expressed in HEK 293 cells.
Clone:: 2F5
Format:: Supplied as a liquid in PBS, 10% glycerol. No preservative added.
Extra Details:: Netrin-1 controls guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Netrin-1 is also involved in tumorigenesis by regulating apoptosis. Netrin-1 promotes atherosclerosis by retaining macrophages in the artery wall. Netrin-1 also governs induced pluripotent stem cell (iPS) formation and improves reprogramming efficiency of human and mouse somatic cells by limiting apoptosis mediated by Netrin-1 receptors DCC or UNC5b. Applications: Suitable for use in ELISA and Blocking. Other applications not tested. Recommended Dilution: Blocking: Inhibits the activation of human and mouse Netrin-1 to human or mouse receptors DCC or UNC5 (KD antibody-Netrin-1 is 1.5nM). Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Shipping Conditions:: Blue Ice