UCHL1 (Ubiquitin C-terminal Hydrolase L1) (Not for Export EU)

Size

£448.00

SKU:: 367930
Purity:: Serum
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Goat
Immunogen:: Synthetic peptide corresponding to NFRKKQIEELKGQEVSPK from human UCHL1.
Format:: Supplied as a liquid. No preservative added.
Extra Details:: Ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) is one of the most abundant proteins in the brain and represents 1-2% of total soluble brain proteins. UCH-L1 activity is thought to cleave polymeric ubiquitin to monomers and to hydrolyze bonds between ubiquitin-protein conjugatges to regenerate ubiquitin monomers. In many degenerative diseases, ubiquitin has been identified as a component of several inclusion bodies and certain of these are associated with UCH-L1 activity. One such inclusion is the Lewy body of Parkinson?s disease. Since a polymorphism has been detected in the UCH-L1 gene, it is suspected to have a role is some forms of Parkinson’s disease. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:71,350 Western Blot: 1:2000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.