Atractyloside, Calcium Salt

Size

£358.00

SKU:: 367007
Molecular Weight:: 783.9
Storage Conditions:: -20°C
Supplier:: United States Biological
CAS Number:: 772298-35-8 free acid
Format:: Pale Yellow Solid
Extra Details:: Atractyloside Calcium Salt is a specific inhibitor of the adenine nucleotide translocase (ANT), which is a mitochondrial ADP/ATP carrier. It is also a proapoptotic ligand of ANT that induces pore formation by ANT, and results in permeabilization of the mitochondria membrane. Studies on rat hearts suggest that Atractyloside inhibits chloride channels from the mitochondrial membrane. It is used to probe the source of procaspase 8 in human fibroblasts and mouse clonal striatal cells, as related to death receptor-mediated apoptosis. Atractyloside induces the release of ahyaluronidase-induced murine WW domain-containing oxidoreductase from cultured COS-7 cells, with respect to tumor necrosis factor cytotoxicity._x000B_ Appearance: Pale Yellow Solid Melting Point: 226-229°C (dec.) Mol. Weight: 783.9 Solubility: DMSO, Methanol Storage: Hygroscopic, -20°C Freezer, Under inert atmosphere