Dynorphin, Pro (Proenkephalin-B, Pdyn, Beta-neoendorphin-dynorphin, Preprodynorphin, Preproenkephalin-B, Dynorphin B-29, Leumorphin)

Size

£761.00

SKU:: 366949
Application:: IHC-Fr
Purity:: Purified by Protein G affinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Mouse
Immunogen:: Linear peptide corresponding to rat Prodynorphin at the C-terminal half sequence, Thyroglobulin-conjugated.
Clone:: Dyn9
Format:: Supplied as a liquid in 0.1M Tris-Glycine, pH 7.4, 150mM sodium chloride, 0.05% sodium azide.
Extra Details:: Proenkephalin-B (UniProt P06300; also known as Beta-neoendorphin-dynorphin, Preprodynorphin) is encoded by the Pdyn gene (Gene ID 29190) in rat species. Proenkephalin B is an opioid polypeptide hormone involved with chemical signal transduction and cell communication. Prodynorphin is a basic building-block of endorphins, the chemical messengers in the brain that appear most heavily involved in the anticipation and experience of pain and the formation of deep emotional bonds critical in learning and memory. Prodynorphin is produced with a signal peptide (aa1-21) and a propeptide (aa22-163) sequence. Following the removal of the signal and propeptide sequences, the protein is further processed by proeolytic cleavages to form Alpha-neoendorphin (aa166-175), Beta-neoendorphin (aa166-174), Big dynorphin (aa202-233; Big Dyn), Dynorphin A(1-17) (aa202-218; Dyn-A17; Dynorphin A); Dynorphin A(1-13) (aa202-214), Dynorphin A(1-8) (aa202-209), Leu-enkephalin (aa202-206 & 221-225), Leumorphin (Dynorphin B-29) (aa221-248), and Rimorphin (aa221-233; Dynorphin B; Dyn-B; Dynorphin B(1-13)). Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (paraffin): 1:20 detects Prodynorphin/Dynorphin B29 immunoreactivity in human midbrain tissue sections. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Shipping Conditions:: Blue Ice