SB 525334 (SB-525334, 6-(2-(tert-Butyl)-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl)quinoxaline)

Size

£304.00

SKU:: 366912
Molecular Weight:: 343.4
Purity:: Highly Purified (~98%)
Storage Conditions:: -20°C
Supplier:: United States Biological
CAS Number:: 356559-20-1
Format:: Supplied as a crystalline solid.
Extra Details:: Synonyms: SB-525334, 6-(2-(tert-Butyl)-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl)quinoxaline Chemical Name: 6-[2-tert-butyl-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl]quinoxaline Molecular Formula: C21H21N5 Molecular Weight: 343.4 CAS Number: 356559-20-1 Purity: ≥98% Applications: FA Appearance: Crystalline solid Description: SB 525334 is a selective and potent inhibitor of the TGF-Beta receptor 1 (ALK5). It exhibits no inhibition of ALK2, ALK3, and ALK6. It blocks the activation of Smad2/3 by TGF-β1 in renal proximal tubule cells and attenuates bleomycin-induced pulmonary fibrosis. Solubility: Soluble in organic solvents such as DMSO. DMSO up to 100mM. Storage: Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.