USP6NL (USP6 N-Terminal Like Protein, RNTRE, TRE2NL, Related to the N-terminus of tre)

Size

£517.00

SKU:: 365537
Purity:: Purified by Protein A and peptide affinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: Recombinant protein corresponding to Met1-Gly292 of human USP6Nl, expressed in E. coli.
Format:: Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Extra Details:: RNTRE is a 97-100kD protein that stably associates in vivo and in vitro with EPS8 via the SH3 domain of the latter. In vitro, RNTRE displayed remarkable preference for binding to the SH3 domain of EPS8, compared with 8 other SH3s. A C-terminal truncated mutant of RNTRE was able to confer proliferative advantage and reduced serum requirement to NIH 3T3 fibroblasts, suggesting a role for RNTRE in cell proliferation. Because the 828aa protein encoded by this cDNA shows homology to the N-terminal region of the TRE oncogene, the authors designated it RNTRE, for 'related to the N terminus of TRE.' RNTRE was shown to be ubiquitously expressed. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.