TXLNa (Taxilin Alpha, IL14, TXLN, HMW-BCGF, High Molecular Weight B-Cell Growth Factor, Interleukin 14)

Size

£524.00

SKU:: 365482
Purity:: Purified by Protein A and peptide affinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: Recombinant protein corresponding to Lys328-Glu531 of human TXLNa, expressed in E. coli.
Format:: Supplied as a liquid in 0.01M PBS, pH7.4, 0.05% Proclin-300, 50% glycerol.
Extra Details:: TXLN interacts with STX3 through its coiled-coil domain. TXLN also interacts with STX1A and STX4. Immunofluorescence and confocal microscopy demonstrated that coexpression of TXLN with STX4 caused relocalization of TXLN from the cytosol to the plasma membrane. Overexpression of TXLN in PC12 cells inhibited human growth hormone exocytosis in response to high potassium levels. The predicted TXLN protein contains 546aa and has a calculated molecular mass of 62kD. It has a long C-terminal coiled-coil domain, 24 potential phosphorylation sites, 1 N-glycosylation site, 10 N-myristoylation sites, and 3 EF-hand motifs. Northern blot analysis detected a major 5.1-kb TXLN transcript in all tissues tested, as well as 2.1- and 1.5-kb TXLN transcripts in heart, liver, and pancreas. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Shipping Conditions:: Blue Ice