365298
TICAM2 (Toll Like Receptor Adaptor Molecule 2, TRAM, TIRAP3, TIRP, Toll/Interleukin-1 Receptor Domain-Containing, TIR domain-containing adapter molecule 2, Toll-like receptor adaptor Protein 3, TRIF-related adapter molecule)
Size
£537.00
- SKU:
- 365298
- Purity:
- Purified by Protein A and peptide affinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Recombinant protein corresponding to aa20-196 of mouse TICAM2, expressed in E. coli.
- Format:
- Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
- Extra Details:
- TIRP is a Toll/interleukin-1 receptor (IL1R) (TIR) domain-containing adaptor protein involved in Toll receptor signaling. The predicted 235aa protein, which is 70% identical to the mouse protein, has a central TIR domain that is most similar to that of TRIF. Northern blot analysis indicated that TIRP is expressed ubiquitously. Transcripts of 3.8, 3.6, and 2.0 kb were detected, and they were differentially expressed in tissues. TIRAP, and TRIF, but not with MYD88, TLR2, or TLR4. Among IRAKs, TIRP interacted with wildtype IRAK2 and IRAKM (IRAK3), both of which lack kinase activity, but it interacted only with kinase-inactive mutants of IRAK1 and IRAK4. Analysis of deletion mutants determined that the TIR domain of TIRP interacted specifically with the TRAF domain of TRAF6; TIRP did not interact with TRAF5. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (paraffin): 5-20ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice