365125
SOD1 (Superoxide Dismutase 1, Soluble, ALS, ALS1, IPOA, Amyotrophic Lateral Sclerosis 1, Adult, Superoxide dismutase [Cu-Zn])
Size
£528.00
- SKU:
- 365125
- Application:
- WB
- Purity:
- Purified by Protein A and peptide affinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Recombinant protein corresponding to Ala2-Pro154 of equine SOD1, expressed in E. coli.
- Format:
- Supplied as a liquid in 0.01M PBS, pH 7.4, 0.05% Proclin-300, 50% glycerol.
- Extra Details:
- Superoxide dismutase 1, solubleis a human protein and gene. This gene encodes one of three forms of the human superoxide dismutase. SOD1 binds copper and zinc ions and is one of three isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic and mitochondrial intermembrane space protein, acting as a homodimer to convert naturally occurring, but harmful, superoxide radicals to molecular oxygen and hydrogen peroxide. Mutations (over 100 identified to date) in this gene have been linked to familial amyotrophic lateral sclerosis. The most frequent mutation are A4V (in the U.S. A.) and H46R (Japan). The most studied ALS mouse model is G93A. Rare transcript variants have been reported for this gene. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. AA Sequence: MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGS- ALKAVCVLK GDGPVHGVIH FEQQQEGGPV VLKGFIEGLT KGDHGFHVHE FGDNTQGCTT AGAHFNPLSK KHGGPKDEER HVGDLGNVTA DENGKADVDM KDSVISLSGK HSIIGRTMVV HEKQDDLGKG GNEESTKTGN AGSRLACGVI GIAP Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice