RNLS (Renalase, MAO-C, C10orf59, FAD-Dependent Amine Oxidase, Monoamine oxidase-C, alpha-NAD(P)H oxidase/anomerase)

Size

£577.00

SKU:: 364928
Purity:: Purified by immunoaffinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: Recombinant protein corresponding to Ala18- Ser150 of rat RNLS, expressed in E. coli.
Format:: Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Extra Details:: The renalase protein is an enzyme which breaks down catecholamines like adrenaline (epinephrine) and noradrenaline (norepinephrine) in the blood circulation. Researchers at Yale School of Medicine who discovered and named renalase in 2005 suggest that the human kidney releases this protein into the bloodstream to regulate blood pressure. The renalase protein consists of a secretory signal peptide, a flavin adenine dinucleotide (FAD)-binding region, and an amine oxidase domain. At least four alternative splicing isoforms have been identified in humans (hRenalase1 to hRenalase4). Only hRenalase1 is detected in human blood samples, which means that hRenalase2 to 4 probably have a different function than hRenalase1. Applications: Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry. Other applications not tested. Recommended Dilution: ELISA: 1:100-1:5000 Western Blot: 1:50-400 Immunocytochemistry: 1:50-500 Immunohistochemistry (frozen): 1:50-500 Immunohistochemistry (paraffin): 1:10-100 Optimal dilutions to be determined by the researcher. AA Sequence: MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- ALL RKEITAPLYL ALWDKAGDIG GRMTTANSPH NPRCTADLGA QYITCTPHYA KKHQNFYEEL LAHGILEPLT SPIKGMEVKE GESNFVAPHG VSSIIKYYLK ESGAEVFLRQ CVTQINLRDN KWEVSEDTGS Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Shipping Conditions:: Blue Ice