RIPK2 (Receptor Interacting Serine Threonine Kinase 2, CCK, CARD3, CARDIAK, GIG30, RICK, RIP2, CARD-containing interleukin-1 beta-converting enzyme-associated kinase, Receptor-interacting 2, RIP-like-interacting CLARP kinase)

Size

£495.00

SKU:: 364911
Purity:: Purified by Protein A and peptide affinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: Recombinant protein corresponding to Met1-Leu294 of mouse RIPK2, expressed in E. coli.
Format:: Supplied as a liquid in 0.01M PBS, pH7.4, 0.05% Proclin-300, 50% glycerol.
Extra Details:: Receptor-interacting serine/threonine-protein kinase 2 is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli. Expression of RICK promoted the activation of caspase-8 and potentiated apoptosis induced by FAS, FADD, CLARP, and caspase-8. Northern blot analysis revealed that RICK is expressed in various human tissues as 2.5- and 1.8-kb mRNAs that differ due to alternative polyadenylation. The authors concluded that RICK is a novel kinase that may regulate apoptosis induced by the FAS receptor pathway. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Shipping Conditions:: Blue Ice