PF4V1 (Platelet Factor 4 Variant 1, CXCL4L1, PF4var1, CXCL4V1, SCYB4V1, SCYB4-V1, CXCL4-V1, Chemokine(C-X-C-Motif)Ligand 4 Variant)

Size

£524.00

SKU:: 364612
Application:: WB
Purity:: Purified by Protein A and peptide affinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: Recombinant protein corresponding to Met1-Ser104 of human PF4V1, expressed in E. coli.
Format:: Supplied as a liquid in 0.01M PBS, pH 7.4, 0.05% Proclin-300, 50% glycerol.
Extra Details:: The PF4V1 gene comprised 3 exons and 2 introns. Exon 1 coded for a 34aa hydrophobic leader sequence that had 70% sequence homology with the leader sequence of PF4. Exon 2 coded for a 42aa segment that was 100% identical with the corresponding segment of the mature PF4 sequence. Exon 3 coded for the 28-residue carboxy-terminal region corresponding to a domain specifying heparin-binding and cellular chemotaxis. Human Gene Mapping Workshop 10.5 assigned the PF4V1 gene to 4q12-q21, the same region as that which carries the PF4, IP10, and MGSA genes. Green et al. (1989) suggested that the polymorphism detected in the PF4 gene by Guzzo et al. (1987) was in fact a polymorphism of the PF4V1 gene.Poncz et al. (1991) demonstrated that the PF4V1 and beta-thromboglobulin genes are located in a region of less than 190 kb. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. AA Sequence: MSPILGYWKI KGLVQPTRLL LEYLEEKYEE HLYERDEGDK WRNKKFELGL EFPNLPYYID GDVKLTQSMA IIRYIADKHN MLGGCPKERA EISMLEGAVL DIRYGVSRIA YSKDFETLKV DFLSKLPEML KMFEDRLCHK TYLNGDHVTH PDFMLYDALD VVLYMDPMCL DAFPKLVCFK KRIEAIPQID KYLKSSKYIA WPLQGWQATF GGGDHPPKSD GSTSGSGHHH HHHSAGLVPR GSTAIGMKET AAAKFERQHM DSPDLGTGGG SGIEGRGSMG YRGSEF-MSSAARSRLT RATRQEMLFL ALLLLPVVVA FARAEAEEDG DLQCLCVKTT SQVRPRHITS LEVIKAGPHC PTAQLIATLK NGRKICLDLQ ALLYKKIIKE HLES Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Shipping Conditions:: Blue Ice