364510
PAG1 (Phosphoprotein Associated With Glycosphingolipid Microdomains 1, CBP, PAG, Csk-Binding Protein, Transmembrane adapter protein PAG, Transmembrane phosphoprotein Cbp)
Size
£531.00
- SKU:
- 364510
- Purity:
- Purified by Protein A and peptide affinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Recombinant protein corresponding to aa160-390 of mouse PAG1, expressed in E. coli.
- Format:
- Supplied as a liquid in PBS, pH 7.4, 0.05% Proclin-300, 50% glycerol.
- Extra Details:
- PAG1 is a type III transmembrane adaptor protein that binds to the tyrosine kinase csk protein. It is thought to be involved in the regulation of T cell activation.Initiation of signal transduction via immunoreceptors depends on interactions of the engaged receptor with glycosphingolipid-enriched membrane microdomains (GEMs), also known as membrane rafts. GEMs are small signaling islets that are relatively resistant to detergent solubilization except by n-alkyl glycosides. Sequence analysis predicted that the 432aa type III transmembrane protein contains a 16aa extracellular domain, a 20aa transmembrane domain, a putative palmitoylation site, and a 397aa cytoplasmic tail with 9 potential tyrosine phosphorylation sites and multiple putative casein kinase II and protein kinase C phosphorylation sites. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (paraffin): 5-20ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice