364500
P2RX7 (Purinergic Receptor P2X, Ligand Gated Ion Channel 7, P2X7, P2X Purinoceptor 7, ATP receptor, Purinergic receptor)
Size
£626.00
- SKU:
- 364500
- Purity:
- Purified by Protein A and peptide affinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Recombinant protein corresponding to Ser47-Val334 of human P2RX7, expressed in E. coli.
- Format:
- Supplied as a liquid in 0.01M PBS, pH7.4, 0.05% Proclin-300, 50% glycerol.
- Extra Details:
- P2X purinoceptor 7 is a protein belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Multiple alternatively spliced variants which would encode different isoforms have been identified although some fit nonsense-mediated decay (NMD) criteria. In experiments using pericyte-containing microvessels isolated from adult rat retina, they found that soon after the onset of streptozotocin-induced diabetes, markedly lower P2X7 agonist concentrations effectively opened pores and triggered apoptosis in the retinal microvasculature. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice