364486
OIT3 (Oncoprotein Induced Transcript 3, LZP, Liver-specific zona pellucida domain-containing protein)
Size
£537.00
- SKU:
- 364486
- Application:
- WB
- Purity:
- Purified by Protein A and peptide affinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Recombinant protein corresponding to Arg251-Asp524 of rat OIT3, expressed in E. coli.
- Format:
- Supplied as a liquid in 0.01M PBS, pH 7.4, 0.05% Proclin-300, 50% glycerol.
- Extra Details:
- OIT3 contains one EGF-like domain and one ZP domain. It may be involved in hepatocellular function and development. OIT3 is liver-specific and is expressed only in the hepatocytes; down-regulated in hepatocellular carcinoma (HCC) and HCC cell lines. LZP contains an N-terminal signal peptide, followed by 3 epidermal growth factor (EGF)-like domains and a zona pellucida (ZP) domain in its C-terminal region. LZP also contains several N-glycosylation sites. The 546aa mouse Lzp protein shares 89% identity with human LZP. Northern blot analysis of several human tissues detected a 2.4-kb transcript only in liver. Northern blot analysis of whole mouse embryos detected 2 Lzp variants that differed in the length of the UTR and the poly(A) signal used. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. AA Sequence: MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- RGLVLSEDNH TCQVPVLCKS SAIEVSVPRE LVGGLELFLT NTSCRGVSNG THVNIIFSLK TCGTVVDVVN DKIVASNLVT GLPKQTPGSS GDIIIRTSKL LIPVTCEFPR LYTISEGYVP NLRNAPLEIR SRNHGIFPFT LEIFKDHEFE EPYRETLPTL KLRDSLYFGI EPLVHVSGLE SLVESCFATP TAKVDEILKY YLIRDGCVSD DSVKQYSSRD HLAKHFQVPV FKFVGKDHKE VFLHCRVLVC GVLDERSRCA QGCHRRVRRE AGED Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice