364438
Ntn4 (Netrin 4, Beta-Netrin, Hepar-derived netrin-like protein)
Size
£524.00
- SKU:
- 364438
- Application:
- IHC-Fr
- Purity:
- Purified by Protein A and peptide affinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Recombinant protein corresponding to aa349-592 of human Ntn4, expressed in E. coli.
- Format:
- Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
- Extra Details:
- Netrin-4 is a novel Netrin more closely related to laminin Beta chain that is broadly expressed in both neural and non-neural tissues. It acts during the development and controls the migration of neurons. The role of Netrin-4 in guiding neurones seems to be mediated by known Netrin-1 receptors: DCC and UNC5H1. Netrin-4 is transcribed in a variety of cells including epithelial cells and vascular endothelial cells. Recent studies suggest a role of Netrin-1 and 4 in the branching morphogenesis in the lung. Netrin-4 promotes angiogenesis by stimulating proliferation and migration of microvascular endothelial cells to the same extent that vascular endothelial growth factor (VEGF). Kidney also express Netrin-4 whose level is down regulated upon ischemia-reperfusion injury. Netrin-4 has been reported to be a novel prognostic marker in breast cancer. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry: 5-20ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice