364280
MYO1G (Myosin IG, Minor Histocompatibility Antigen HA-2)
Size
£537.00
- SKU:
- 364280
- Application:
- WB
- Purity:
- Purified by Protein A and peptide affinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Recombinant protein corresponding to Val754-Thr1018 of mouse MYO1G, expressed in E. coli.
- Format:
- Supplied as a liquid in 0.01M PBS, pH 7.4, 0.05% Proclin-300, 50% glycerol.
- Extra Details:
- Precursor of the minor histocompatibility antigen HA-2. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and their expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. AA Sequence: MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- VRAHLIE LQRRFQAARQ PPLYGRDLVW PTPPAVLQPF QDTCRVLFSR WRARQLVKNI PPSDMIQIKA KVAAMGALQG LRQDWGCQRA WARDYLSSDT DNPTASHLFA EQLKALREKD GFGSVLFSSH VRKVNRFRKS RDRALLLTDR YLYKLEPGRQ YRVMRAVPLE AVTGLSVTSG RDQLVVLHAQ GYDDLVVCLH RSQPPLDNRI GELVGMLAAH CQGEGRTLEV RVSDCIPLSQ RGARRLISVE PRPEQPEPDF QSSRSTFT Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice