364152
MIP1a (Macrophage Inflammatory Protein 1 Alpha, CCL3, MIP1-A, SCYA3, Chemokine C-C-Motif Ligand 3, Small Inducible Cytokine A3, Homologous To Mouse Mip-1a, Tonsillar Lymphocyte LD78 Alpha Protein)
Size
£433.00
- SKU:
- 364152
- Purity:
- Purified by immunoaffinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Recombinant protein corresponding to Ala27-Ala92 of human MIP1a, expressed in E. coli.
- Format:
- Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
- Extra Details:
- MIP-1alpha plays an important role in the development and regulation and recruitment of leukocytes. CCL3 is produced by a variety of cells, including lymphocytes, fibroblasts, and epithelial cells, as well as both resident and recruited monocytes macrophages. CCL3 has roles in the compartmentalization and mobilization of myeloid precursor cells (MPCs). Through the use of CCR1 knockout mice, CCL3 has been shown to mediate the mobilization of MPCs from the bone marrow, as well as having regulatory effects on MPCs and acting to stimulate mature MPCs, but CCL3 inhibits immature cells. CCL3 has been reported to be chemotactic for both neutrophils and monocytes in vitro and in vivo in mice. In humans and higher primates, however, predominantly monocytic cellular infiltrates will accumulate in response to direct injection of CCL3. Applications: Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry. Other applications not tested. Recommended Dilution: ELISA: 1:100-1:5000 Western Blot: 1:50-400 Immunohistochemistry (frozen): 1:50-500 Immunohistochemistry (paraffin): 1:10-100 Immunocytochemistry: 1:50-500 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap
- Shipping Conditions:
- Blue Ice