364140
MHCDG (Major Histocompatibility Complex Class II Invariant Chain, CD74, HLA-DG, HLADG, DHLAG, Ia-GAMMA, HLA class II histocompatibility antigen gamma chain, Ia antigen-associated invariant chain, HLA-DR antigens-associated invariant chain)
Size
£537.00
- SKU:
- 364140
- Application:
- WB
- Purity:
- Purified by Protein A and peptide affinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Recombinant protein corresponding to Leu65-Gln277 of rat MHCDG, expressed in E. coli.
- Format:
- Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
- Extra Details:
- In addition to functioning as an MHC class II chaperone, Cd74 was required for B-cell development in mice. B cells from mice lacking Cd74 had a low response to T-independent type II antigen and could not proliferate after mice were injected with antigen. Study of cell surface markers showed a developmental arrest that prevented immature virgin B cells from becoming mature B cells in the periphery. This block was independent of MHC class II expression and was an intrinsic feature of B cells that correlated with the amount of Cd74. Using immunohistochemical and confocal microscopy analyses, Schori et al. (2007) showed that transgenic mice that weakly expressed the p41 Cd74 isoform on an MHC I-Ab genetic background recovered better from central nervous system (CNS) injuries than did wildtype mice. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap
- Shipping Conditions:
- Blue Ice