MEP1b (Meprin A Beta, PPH Beta, Endopeptidase-2, Meprin B, PABA Peptide Hydrolase, N-benzoyl-L-tyrosyl-P-amino-Benzoic Acid Hydrolase Subunit Beta)

Size

£495.00

SKU:: 364110
Purity:: Purified by Protein A and peptide affinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: Recombinant protein corresponding to Trp433-Tyr679 of rat MEP1b, expressed in E. coli.
Format:: Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Extra Details:: Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes and in leukocytes and certain cancer cells. Mature meprins are oligomers of evolutionarily related, separately encoded alpha and/or beta subunits. Homooligomers of meprin-alpha (MEP1A) are secreted; oligomers containing meprin-beta are associated with the plasma membrane. Mep1b-null mice were born at half the expected mendelian ratio, but those that survived developed normally and were viable and fertile. Mutant mice lacked membrane-associated Mep1a in kidney and intestine, and microarray analysis indicated that renal gene expression profiles were different than those of wildtype mice. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Shipping Conditions:: Blue Ice