363905
LAMb4 (Laminin Beta 4, Laminin beta-1-related protein)
Size
£626.00
- SKU:
- 363905
- Application:
- WB
- Purity:
- Purified by Protein A and peptide affinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Recombinant protein corresponding to Asn1543-Cys1759 of human LAMb4 expressed in E. coli.
- Format:
- Supplied as a liquid in 0.01M PBS, pH 7.4, 0.05% Proclin-300, 50% glycerol.
- Extra Details:
- Laminins (LN)are the major non-collagenous component of the basal lamina, such as those on which cells of an epithelium sit. They are a family of glycoproteins that are an integral part of the structural scaffolding of basement membranes in almost every animal tissue. Laminins are secreted and incorporated into cell-associated extracellular matrices. Dysfunctional structure of one particular laminin, laminin-2, is the cause of some forms of muscular dystrophy. Laminin-2 is composed of an alpha 2, a beta 1 and a gamma 1 chains. This laminin's distribution includes the brain and muscle fibers. In muscle, it binds to alpha dystroglycan via the G domain, and via the other end binds to the extracellular matrix. Progeria is the result of a defect in the prolaminin receptor that prevents the cleaving and activation of prolaminin into laminin. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice