363866
KREMEN1 (Kringle Containing Transmembrane Protein 1, KRM1, KREMEM1, Dickkopf receptor, Kringle-containing protein marking the eye and the nose)
Size
£626.00
- SKU:
- 363866
- Application:
- WB
- Purity:
- Purified by Protein A and peptide affinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Recombinant protein corresponding to Lys157-Gly390 of human KREMEN1 expressed in E. coli.
- Format:
- Supplied as a liquid in 0.01M PBS, pH 7.4, 0.05% Proclin-300, 50% glycerol.
- Extra Details:
- Kremen protein 1 is a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The deduced 473aa protein contains an N-terminal signal sequence, followed by a kringle domain, a WSC domain, a CUB domain, a transmembrane domain, and an intracellular C-terminal tail. Northern blot analysis detected a 5.0kb transcript in all mouse tissues examined, with highest expression in heart, lung, kidney, and skeletal muscle. In addition, testis expressed transcripts of 3.0 and 2.3kb. Krm1 expression was detected in the apical ectodermal ridge of limb buds, myotome, and sensory organs of mouse embryos and increased during development. Krm1 expression increased during differentiation in mouse myoblast and neuroblastoma cell lines. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice