KLK4 (Kallikrein 4, ARM1, EMSP1, KLK-L1, PRSS17, PSTS, Enamel Matrix, prostate, Kallikrein-Related Peptidase 4, Enamel matrix serine proteinase 1, Serine protease 17, Kallikrein-like protein 1)

Size

£482.00

SKU:: 363850
Purity:: Purified by Protein A and peptide affinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: Recombinant protein corresponding to aa27-254 of human KLK4 expressed in E. coli.
Format:: Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Extra Details:: Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. KLK4 was predominantly expressed in nuclei of basal cells in the prostate epithelium, in keeping with its distribution in prostate cancer cells in vitro. Adenovirus-mediated KLK4 expression dramatically induced proliferation of prostate cancer cells, at least in part, through significant alterations in cell cycle regulatory gene expression. Consistent with this data, small interfering RNA-mediated knockdown of endogenous KLK4 in LNCaP prostate cancer cells inhibited cell growth. Applications: Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry. Other applications not tested. Recommended Dilution: ELISA: 1:100-5000 Western Blot: 1:50-400 Immunohistochemistry (frozen): 1:50-500 Immunohistochemistry (paraffin): 1:10-100 Immunocytochemistry: 1:50-500 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Shipping Conditions:: Blue Ice