363774
ITGa1 (Integrin Alpha 1, CD49-A, CD49a, ITG-A1, VLA1, CD49 antigen-like family member A, Laminin and collagen receptor)
Size
£537.00
- SKU:
- 363774
- Purity:
- Purified by immunoaffinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Recombinant protein corresponding to Lys113-Trp380 of chicken ITGa1 expressed in E. coli.
- Format:
- Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
- Extra Details:
- CD49a encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding. The integrin alpha-1 chain associates with the beta-1 chain (ITGB1) to form a heterodimer that functions as a dual laminin/collagen receptor in neural cells and hematopoietic cells. It has a role in cell attachment and neurite outgrowth on laminin and collagen as well as in peripheral nerve regeneration. Applications: Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry. Other applications not tested. Recommended Dilution: ELISA: 1:100-5000 Western Blot: 1:50-400 Immunohistochemistry (frozen): 1:50-500 Immunohistochemistry (paraffin): 1:10-100 Immunocytochemistry: 1:50-500 Optimal dilutions to be determined by the researcher. AA Sequence: MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF-KGGFLACG PLYAYKCGRL HYTTGVCSNV SSTFETVKAV APSVQECKTQ LDIVIVLDGS NSIYPWESVT AFLNSLLRNM DIGPQQTQVG IVQYGQTVVH EFYLNTYSTT EEVMDAALRI RQRGGTQTMT ALGIDTAREE AFTEAHGARR GVQKVMVIVT DGESHDNYRL QEVIDKCEDE NIQRFAIAIL GSYSRGNLST EKFVEEIKSI ASKPTEKHFF NVSDELALVT IVEALGERIF ALEATTDQQA ASFEMEMSQA GFSAHYSQDW Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice