363655
IL18RAP (Interleukin 18 Receptor Accessory Protein, CDw218b, CD218-B, IL-1R7, ACPL, Accessory protein-likeL, CD218 antigen-like family member B, IL-1R accessory protein-like, Interleukin-1 receptor 7, Interleukin-18 receptor beta)
Size
£524.00
- SKU:
- 363655
- Purity:
- Purified by immunoaffinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Recombinant protein corresponding to Leu310-Ser451 of human IL18RAP, expressed in E. coli.
- Format:
- Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
- Extra Details:
- Interleukin 18 receptor accessory protein is an accessory subunit of the heterodimeric receptor for IL18. This protein enhances the IL18 binding activity of IL18R1 (IL1RRP), a ligand binding subunit of IL18 receptor. The coexpression of IL18R1 and this protein is required for the activation of NF-kappaB and MAPK8 (JNK) in response to IL18. IL18RAP is predicted to contain a 14aa signal peptide, a 342aa extracellular (Ig superfamily-like) segment, a single transmembrane region, and a 222aa cytoplasmic domain that is 32% identical to IL1R1. Northern blot analysis revealed that IL18RAP mRNA, present predominantly as a 3.8-kb product, was expressed strongly in peripheral blood leukocytes, spleen, lung, and, to a lesser extent, in colon, but not in any other tissue tested. Applications: Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry. Other applications not tested. Recommended Dilution: ELISA: 1:100-1:5000 Western Blot: 1:50-400 Immunocytochemistry: 1:50-500 Immunohistochemistry (frozen): 1:50-500 Immunohistochemistry (paraffin): 1:10-100 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice