IkBKb (Inhibitor Of Kappa-Light Polypeptide Gene Enhancer In B-Cells Kinase Beta, IKK2, NFKBIKB, IKK-beta, IKKB, I-kappa-B kinase 2, Nuclear factor NF-kappa-B inhibitor kinase beta)

Size

£537.00

SKU:: 363612
Purity:: Purified by Protein A and peptide affinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: Recombinant protein corresponding to Met1-Trp231 of mouse IkBKb, expressed in E. coli.
Format:: Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Extra Details:: IKK-beta also known as inhibitor of nuclear factor kappa-B kinase subunit beta is an enzyme that serves as a protein subunit of IkappaB kinase, which is a component of the cytokine-activated intracellular signaling pathway involved in triggering immune responses. Its activity causes activation of a transcription factor known as Nuclear Transcription factor kappa-B or NF-kappaB. Activated IKK-beta phosphorylates a protein called the inhibitor of NF-kappaB, IkappaB (IkappaBalpha), which binds NF-kappaB to inhibit its function. Phosphorylated IkappaB is degraded via the ubiquitination pathway, freeing NF-kappaB, and allowing its entry into the nucleus of the cell where it activates various genes involved in inflammation and other immune responses.IKK-beta plays a significant role in brain cells following a stroke. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Shipping Conditions:: Blue Ice